Early Downward Trends in Neurodevelopmental Disorders Following Removal of Thimerosal-Containing Vaccines

Lun, 17/12/2012 - 08:01

ABSTRACT Contemporaneously with the epidemic rise in neuro-
developmental disorders (NDs), first observed in the United States
during the 1990s, the childhood immunization schedule was
expanded by the U.S. Centers for Disease Control and Prevention
(CDC) to include several additional thimerosal-containing vaccines
(TCVs). On July 7, 1999, a joint recommendation was made by the
American Academy of Pediatrics (AAP) and the U.S. Public Health
Service (PHS) to remove thimerosal from vaccines. A two-phase
study was undertaken to evaluate trends in diagnosis of new NDs
entered into the Vaccine Adverse Event Reporting System
(VAERS) and the California Department of Developmental Services
(CDDS) databases on a reporting quarter basis, from 1994 through
2005. Significant increasing trends in newly diagnosed NDs were
observed in both databases 1994 through mid-2002. Significant
decreasing trends in newly diagnosed NDs were observed in both
databases from mid-2002 through 2005. The results indicate that
the trends in newly diagnosed NDs correspond directly with the
expansion and subsequent contraction of the cumulative mercury
dose to which children were exposed from TCVs through the U.S.
immunization schedule.